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Tuesday, August 4, 2020 | History

3 edition of Growth Hormone Regulation of Hepatic Drug-Metabolising Enzymes in Humans and Rats found in the catalog.

Growth Hormone Regulation of Hepatic Drug-Metabolising Enzymes in Humans and Rats

Eva Rasmussen

Growth Hormone Regulation of Hepatic Drug-Metabolising Enzymes in Humans and Rats

by Eva Rasmussen

  • 292 Want to read
  • 11 Currently reading

Published by Uppsala Universitet .
Written in English

    Subjects:
  • Pharmacology,
  • Medical

  • Edition Notes

    SeriesComprehensive Summaries of Uppsala Dissertations, 816
    The Physical Object
    FormatPaperback
    ID Numbers
    Open LibraryOL12854006M
    ISBN 109155443702
    ISBN 109789155443702

    Practice: Human impact on animal populations. Practice: Heat generation in brown fat. Practice: Control of glucose levels. Practice: Regulation of growth hormone. This is the currently selected item. Practice: Measuring hormone levels. Practice: The effects of high blood pressure on the heart. Kato R, Takahashi A () Thyroid hormone and activities of drug-metabolizing enzymes and electron transport systems of rat liver microsomes. Mol Pharmacol 4: – PubMed Google Scholar Kato R, Yamazoe Y, Shimada M, Murayama N, Kamataki T () Effect of growth hormone and ectopic transplantation of pituitary gland on sex-specific forms.

      Activities of drug‐metabolizing enzymes (DMEs) are known to change throughout the course of physical and sexual maturation, with the greatest variability noted during infancy and adolescence. The mechanisms responsible for developmental regulation of DME are currently unknown. Growth hormone regulation of male-specific rat liver Ps 2A2 and 3A2: Induction by intermittent growth hormone pulses in male but not female rats rendered growth hormone deficient by neonatal.

      Waxman DJ, Ram PA, Pampori NA, Shapiro BH () Growth hormone regulation of male-specific rat liver Ps 2A2 and 3A2: induction by intermittent growth hormone pulses in male but not female rats rendered growth hormone deficient by neonatal monosodium glutamate. Mol Pharmacol – PubMed Google Scholar. Liver Phosphorylase Deficiency (Gsd Types 6 And 9) Normal liver glycogen phosphorylase activity involves a complex cascade of events that activates the enzyme capacity to degrade liver glycogen before and after the debranching step. 66 Consequently, low hepatic phosphorylase activity may result from a defect in any of the steps of activation.


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Growth Hormone Regulation of Hepatic Drug-Metabolising Enzymes in Humans and Rats by Eva Rasmussen Download PDF EPUB FB2

Sex differences in pharmacokinetics and pharmacodynamics characterize many drugs and contribute to individual differences in drug efficacy and toxicity. Sex-based differences in drug metabolism are the primary cause of sex-dependent pharmacokinetics and reflect underlying sex differences in the expression of hepatic enzymes active in the metabolism of drugs, steroids, fatty.

Kennedy MJ, Davis DA, Smith NB, Gaedigk A, Pearce RE, Kearns GL. Absence of Effect of Recombinant Human Growth Hormone (rhGH) on Activities of Cytochrome PA2 (CYP1A2), N-acetyltransferase 2 (NAT-2), Xanthine Oxidase (XO) and Cytochrome PD6 (CYP2D6) in Pediatric Patients with Growth Hormone Deficiency.

Clinical Therapeutics. In by:   Sex Differences in Hepatic Drug Metabolism. Sex-based differences characterize the metabolism of many drugs commonly used in humans (Gandhi et al., ; Anderson, b; Schwartz, ); 6 to 7% of new drug applications that include a sex analysis show at least 40% difference in pharmacokinetics between men and women (Anderson, b).For example, acetaminophen Cited by: It is known that changes in growth hormone and sex steroids that occur during adolescence can affect the expression of drug-metabolizing enzymes (26, 27).

The observed enhanced N-oxide formation Author: Mj Kennedy. Hepatic drug metabolism. Various drug-metabolizing enzymes (DMEs) mediate hepatic drug metabolism, and expression and activity levels of these enzymes determine CL int of drugs.

To date, among 18 CYP families that have been identified in humans, enzymes in three CYP families (CYP1, CYP2, and CYP3) are responsible for most phase I by:   We investigated the roles of HNF6, C/EBPα, and RXRα in the regulation of human female-predominant CYP3A4, mouse female-specific CYP3A41, and rat male-specific CYP3A2 expression by GH secretion patterns using HepG2 cells, growth hormone receptor (GHR) knockout mice as well as rat models of orchiectomy and hypophysectomy.

Correlations between t½ and hepatic drug oxidases were weak, even when allowance was made for variation in liver size. Thus, the rate of drug metabolism in vivo assessed by measuring AP t½ does not appear to be closely related to the activity of some hepatic drug‐metabolizing enzymes.

Conversely, the ultradian rhythm in growth hormone secretion characterized as masculine is responsible for the occurrence 12 of a fold higher level of hepatic drug metabolism.

ioned above, since most of the hepatic drug metabolizing enzymes represent the combined activities of several forms of P, it is important that the regulatory. In conclusion, the present study indicates that neonatal MSG-treatment pro- duces a useful animal model for studies on the growth hormone regulation of drug metabolizing enzymes, but also showed that the animals are not equivalent to hypophysectomized rats in the profile of cyto- chrome P isozymes.

REFERENCES 1. Kato, Metab. Rev. 3, 1. D.J. Waxman, P.A. Ram, N.A. Pampori, B.H. ShapiroGrowth hormone regulation of male-specific rat liver Ps 2A2 and 3A2: induction by intermittent growth hormone pulses in male but not female rats rendered growth hormone deficient by neonatal monosodium glutamate.

The liver responds to estrogens and growth hormone (GH) which are critical regulators of body growth, gender-related hepatic functions, and intermediate metabolism. The effects of estrogens on liver can be direct, through the direct actions of hepatic ER, or indirect, which include the crosstalk with endocrine, metabolic, and sex-differentiated.

Effects of Hepatic Drug-metabolizing Enzyme Induction on Clinical Pathology Parameters in Animals and Man DANIELA ENNULAT 1,DANA WALKER 2,FRANCES CLEMO 3,MICHAL MAGID-SLAV 1,DAVID LEDIEU 4,MARK GRAHAM 5, SUZANNE BOTTS 6, AND LAURA BOONE 7 1GlaxoSmithKline, King of Prussia, Pennsylvania, USA 2Bristol-Myers Squibb, East Syracuse, New York, USA 3Baxter.

An increase in the rate of synthesis of an enzyme due to the presence of an inducer which acts to derepress the gene responsible for enzyme synthesis.

| Explore the latest full-text research PDFs. Intact, hypophysectomized (HX), and HX rats supplemented with pulsatile growth hormone (GH) were treated with corn oil or EB and the effects on hepatic P expression were determined.

In the present study, changes in the mRNAs of two major forms of hydroxysteroid sulfotransferases (STs), ST2A1 and ST2A2, have been determined in different growth hormone (GH) states. Hepatic ST2A1 mRNA was detected in both sexes of mature Sprague-Dawley rats.

The level was 5 times higher in the females than in the males. ST2A1 mRNA was undetectable in GH-deficient animals, such as. However, little information is available regarding the effects of the human menstrual cycle or the rat estrous cycle on expression and activity of cytochrome P (CYP) isoforms.

The present study was carried out to determine the expression and activity of CYP-dependent drug-metabolizing enzymes in the liver and ovary during the estrous cycle.

Genes coding for cytochrome P are regulated by endogenous hormones such as the growth hormone, corticosteroids, thyroid, and sex hormones. Secretion of these hormones is regulated by the respective hypothalamus–pituitary–secretory organ axes.

Since the brain sends its serotonergic projections from the raphe nuclei to the hypothalamus, we have assumed that damage to these nuclei.

Various hormonal and monoaminergic systems play determinant roles in the regulation of several cytochromes P (Ps) in the liver. Growth hormone (GH), prolactin, and insulin are involved in.

Prolactin is a polypeptide hormone with over separate biologic activities. Its serum level is increased during pregnancy and lactation, and it has been reported that pregnancy and lactation affect drug and steroid metabolism in mice and humans.

Several studies reported that pregnancy or lactation influences liver cytochrome P (P) expression and its activity, affecting the. The hypothesis that the plasma pattern of GH regulates hepatic steroid metabolism in the rat was studied in two different animal models: (1) Different plasma patterns of GH were achieved by administration of human GH (hGH) at different frequencies or by infusing the hormone continuously by means of Alzet osmotic minipumps to hypophysectomized.

In rats, the onset of the sexually dimorphic pattern of growth hormone (GH) secretion and increased hepatic GH-binding capacity at puberty are temporally correlated with the sex-dependent expression of some hepatic cytochrome P enzymes involved in steroid metabolism.() Growth hormone regulation of male-specific rat liver Ps 2A2 and 3A2: induction by intermittent growth hormone pulses in male but not female rats rendered growth hormone deficient by neonatal monosodium glutamate.

Mol Pharmacol – Waxman, D.J., P.A. Ram, N.A. Pampori, and B.H. Shapiro (). Growth hormone regulation of male-specific rat liver Ps 2A2 and 3A2: Induction by intermittent growth hormone pulses in male but not female rats rendered growth hormone deficient by neonatal monosodium glutamate.

Mol. Pharmacol. 48, – PubMed Google Scholar.